mtDNA
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An A to G point mutation
at position 3243 on the
Mitochondrial DNA
causes MELAS and MIDD.
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  Ragged Red Fibres

In the images below, Gomori trichrome stain has been used to stain the mitochondria red.

Image of Ragged Red Fibre
The above muscle fibre has mild mitochondrial proliferation.

Image of Ragged Red Fibre
In half of the above muscle fibre, mitochondria have replaced virtually all the other cell's structures.

© Tufts University, 1999. Mitochondrial Disease.

See Also
Ragged Red Fibres


Author: Andy Collinson. Although I don't have any medical qualifications, as a sufferer of Diabetes, Deafness and Tinnitus caused by the A3243G mtDNA defect, I do have a very keen interest in the subject.

Date Page Updated: 25 April 2005

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