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A3243G
mtDNA |
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Donations welcome. |
An A to G point mutation
at position 3243 on the Mitochondrial DNA causes MELAS and MIDD. |
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Epidemiology of A3243GHere are some estimates of the numbers of people affected by the A3243G mtDNA point mutation. CarriersA study, 1, has shown that there are 16.3 per 100,000 of the adult population carry this gene defect. This study showed that the point mutation has occurred many times, (at least 9), in the population and that it does not show any prevalence for a particular race or sex. On this basis, here are some extrapolations:
DiabetesOther studies have shown that the A3243G mtDNA point mutation is a significant cause of Diabetes, with values ranging from 0.5% to 2.5% depending on the selection criteria of the population being studied. DeafnessSimilarly, a study, 3, has shown that the A3243G mtDNA point mutation is a significant cause of Sensorineural Hearing Loss, with about 1.7% being caused by A3243G values ranging from 0.5% to 2.5% depending on the selection criteria of the population being studied. Author: Andy Collinson. Although I don't have any medical qualifications, as a sufferer of Diabetes, Deafness and Tinnitus caused by the A3243G mtDNA defect, I do have a very keen interest in the subject. Date Page Updated: 25 April 2005
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