A3243G
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Complex V, (five).
Complex V (five) is part of the Electron Transport Chain of
Oxidative Phosphorylation, inside Mitochondria.
Complex V (five) is the last stage of Oxidative Phosphorylation.
The first four stages have converted the Pyruvate to Carbon Dioxide CO2
and Water H2O. During each of these stages, protons H+ have been pumped
across the mitochondrial membrane and created an electro-chemical gradient.
The final step undertaken by Complex V (five) is to convert ADP into ATP. It
does this by an enzyme called ATP Synthase.
ATP Synthase is comprised of 2 mtDNA encoded subunits and 14 Nuclear DNA encoded
subunits.
ATP Synthase is a fascinating enzyme which, driven by the returning protons,
rotates an inner core 120 degrees to "compress" ADP + P to form ATP
See Also
ADP
ATP
Complexes I to V (one to five)
Oxidative Phosphorylation
Pyruvate
Author: Andy Collinson.
Although I don't have any medical qualifications,
as a sufferer of Diabetes, Deafness and Tinnitus caused by the A3243G mtDNA defect,
I do have a very keen interest in the subject.
Date Page Updated:
25 April 2005
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