A3243G
- Jargon
A-Z
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
A-Z
COX
COX is an abbreviation of "Cytochrome c OXidase".
COX is an enzyme inside the Mitochondria.
Inside the Inter Membrane Space of Mitochondria are water soluble molecules called "Cytochrome
c". Within the thickness of the Inner Membrane of Mitochondria are two enzymes. Both of these
enzymes affect "Cytochrome c", the first Reducing it and the second Oxidising
it, hence the names "Cytochrome c Reductase" and "Cytochrome c Oxidase".
Cytochrome c Oxidase is assembled inside the Mitochondria from several
sub-units. One of these sub-units is encoded by mtDNA and the rest by Nuclear
DNA.
|
Note: COX is also an abbreviation of Cyclo OXygenase, which comes in two isomers usually
abbreviated to cox1 and cox2. Cyclo Oxygenase is an important enzyme in the
human body involved in the production of prostaglandins. In turn prostaglandins
are involved with many biochemical reactions, including inflammation response to tissue damage. Interestingly,
NSAIDs
such as Ibuprofen work by stopping Cyclo Oxygenase working fully, hence reducing
inflammation. Cyclo Oxygenase helps protect the stomach from the vicious
digestive juices of the stomach, then when NSAIDs are taken orally, this can potentially lead to stomach ulcers. |
Do not get confused between the two abbreviations of COX! They have nothing to
do with each other.
See Also
Mitochondria
mtDNA
Oxidation
Reduction
Author: Andy Collinson.
Although I don't have any medical qualifications,
as a sufferer of Diabetes, Deafness and Tinnitus caused by the A3243G mtDNA defect,
I do have a very keen interest in the subject.
Date Page Updated:
25 April 2005
|
|
Translate:
