What's New on A3243G

August 2005

Updated Pages:
The CoQ10 Treatment page has been rewritten. 

New Abstracts :

Go	Date	Title
	2003 Jan	Comparative bioavailability of two novel coenzyme Q10 preparations in humans.

June & July 2005

62 Abstracts were added to the Abstract database by Carl:
All the known Abstracts, relating to A3243G, MELAS, MIDD etc, up to 2003 have now been added. It will now be sensible to move onto more recent Abstracts. As any new Abstracts are added, they will be listed here in the What's New page. Many thanks to Carl for his ongoing efforts.

May 2005

Feature Reinstated:
The Forum has been re-programmed from a simple Microsoft one to a proper database driven one. 

April 2005

Feature Removed:
The Forum Pages have been removed. This feature was hijacked by malicious program on the web. It was either 'harvesting' email addresses, and /or placing links to many other web sites - ready for search engines to link to. The forum will return once I have had chance to program one of my own.

Feature Removed:
The Search Page has been removed. This feature only worked intermittently and was outside my control. However, the Abstracts now have a Search feature and this is where the majority of information is to be searched.

New Book Review:
Dr Bernstein's Diabetes Solution

Translator added:
   Click on the flag at the top of the page to translate the entire website into French, Spanish, German or Italian.
   Many thanks to Sean Turner for funding this for the first year.

March 2005

Abstracts :
Abstracts are now in a Database - much easier to maintain on the web site.

New Jargon Words :
Asymptomatic, Oligosymptomatic, Symptomatic.
Aminoacylation

New Book Review :
The Seven Daughters of Eve

Statistics :
Statistics page updated.
Hit counter added.

February 2005

New Menu option Statistics
    Languages / Countries of visitors - 66 languages / countries after 1 month!

January 2005

New Information Page
    In a nutshell - how the A3243G mtDNA causes problems

New Menu option Media
    Professor Jacobs collects Descartes Award for mitochondrial research team

December 2004

Continued changes in the background of the website.
 

November 2004

Extensive work undertaken to revamp the Abstracts into a database format.
 

May to October 2004

No changes these months.
 

April 2004

New Jargon Words :
COX Negative, .

March 2004

New Jargon Words :
COX, Hypoparathyroidism .

Updated Jargon Words :
A3243G.

General :
The Links page has some new links.

February 2004

No changes this month.
 

January 2004

No changes this month.
 

December 2003

No changes this month.
 

November 2003

No changes this month.
 

October 2003

New Abstracts :

Go	Date	Title
	2003 Aug	The Spectrum of Systemic Involvement in Adults Presenting with Renal Lesion and Mitochondrial tRNA(Leu) Gene Mutation.
	2003 Apr	[Dichloroacetate treatment for adult patients with mitochondrial disease]

September 2003

New section :
( available from the Side Navigation Bar ) is :-

• Books :- These are reviews of relevant books.

New Book Review :
MELAS Angels.

New Treatment :
Contra Indicated (Not Recommended) Treatments

New Jargon Words :
Carnitine.

New Image :
Carnitine.

New Abstracts :

Go	Date	Title
	2003 Sep	MELAS: clinical phenotype and morphological brain abnormalities.
	2003 Aug	Pelvic lymphocyst infection associated with maternally inherited diabetes mellitus.
	2003 Aug	[Mitochondrial DNA mutations in patients with chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome]
	2003 Jun	Study on the relationship between mitochondrial gene mutation and latent autoimmune diabetes mellitus in adults.
	2003 Jan	The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu.
	1999 Feb	Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR). Free full text of article available.
	1999 Jan	[Diabetes mellitus associated with the A3243G mutation of mitochondrial DNA. Apropos a case]
	1998 Dec	A False-Positive Diagnosis for the Common MELAS (A3243G) Mutation Caused by a Novel Variant (A3426G) in the ND1 Gene of Mitochondria DNA.
	1998 Nov	Detection of MELAS A3243G point mutation in muscle, blood and hair follicles.
	1998 Nov	Mitochondrial DNA in idiopathic cardiomyopathy.
	1998 Oct	Diagnosis of mitochondrial disease: assessment of mitochondrial DNA heteroplasmy in blood.
	1998 Oct	Detection and quantification of the A3243G mutation of mitochondrial DNA by ligation detection reaction.
	1998 Oct	New sensitive method for the detection of the A3243G mutation of human mitochondrial deoxyribonucleic acid in diabetes mellitus patients by ligation-mediated polymerase chain reaction. Free full text of article available.
	1998 Apr	A tRNA suppressor mutation in human mitochondria.
	1996 Oct	Acute pancreatitis in an infant with lactic acidosis and a mutation at nucleotide 3243 in the mitochondrial DNA tRNALeu(UUR) gene.
	1996 Jan	MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy.

August 2003

No changes this month.
 

July 2003

No changes this month.
 

June 2003

New sections
( available from the Side Navigation Bar ) are :-

• Reviews :- These are Scientific Papers which have been summarised.
• Treatments :- These are known Treatments for MIDD and MELAS. These pages are still under development. If you can help with these, please contact me.

New Jargon Words :
PCR, Threshold.

May 2003

No changes this month.
 

April 2003

The Support Group, Newsletter and Privacy pages have been updated.

New Jargon Words :
MERRF.

Updated Jargon Words :
Ragged Red Fibres.

New Abstracts :

Go	Date	Title
	2003 May	Executive and visuospatial deficits in patients with chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome.
	2003 Apr	A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort.
	2001 Nov	Hearing impairment is common in various phenotypes of the mitochondrial DNA A3243G mutation.
	2001 Nov	mtDNA disease in the primary care setting.
	2001 Sep	Retrospective study of a large population of patients affected with mitochondrial disorders: clinical, morphological and molecular genetic evaluation.

March 2003

No changes this month.
 

February 2003

The Information Page has a new section - Reviews
    Mitochondrial Diabetes

General :
The Links page has some new links.

New Jargon Words :
Cybrid Cells.

Updated Jargon Words :
Diabetes, mtDNA.

New Abstracts :

Go	Date	Title
	2002 Sep	Insulin resistance in patients with the mitochondrial tRNA(Leu(UUR)) gene mutation at position 3243.
	2002 May	Mitochondrial diabetes: pathophysiology, clinical presentation, and genetic analysis.
	2002 Feb	Histochemical and molecular genetic study of MELAS and MERRF in Korean patients.

January 2003

No changes this month.
 

December 2002

General :
The Links page has been reorganised to make it easier to use.

Updated Information Pages :
Variety of symptoms caused by the A3243G mtDNA point mutation.

New Image :
Ragged Red Fibres,

New Jargon Words :
DNA, Mitotic Tissues.

Updated Jargon Words :
CPEO, Post Mitotic Tissues, Ragged Red Fibres.

New Abstracts :

Go	Date	Title
	2002 Mar	Intergenerational transmission of pathogenic heteroplasmic mitochondrial DNA.
	2001 Dec	Mitochondrial 3243 BP mutation: a case report.

Copyright © 2002 - Andy Collinson.
All Rights Reserved.